Monkeypox is transmitted primarily through close contact and respiratory transmission. The source of infection is associated with contact with infected animals, but human-to-human transmission is rare. It is generally believed that native African rodents, such as Gambian giant rats and squirrels, may be the hosts of monkeypox virus. Monkeypox is caused by infection with the monkeypox virus and has symptoms similar to smallpox, including fever, headache, fatigue, muscle pain and swollen lymph nodes with a subsequent rash. Humans become infected with monkeypox mainly through bites from infected animals or direct contact with blood, body fluids, or skin wounds of infected animals. The virus can enter the body through broken skin, respiratory tracts, or mucous membranes, such as the eyes, nose, or mouth and thereby. Monkeypox is usually transmitted from animals to humans, and occasionally human-to-human transmission of monkeypox can occur. Respiratory infection is also generally considered possible during direct, prolonged face-to-face contact, for example, through the transmission of large numbers of respiratory droplets containing the virus. In addition, monkeypox can be transmitted through direct contact with bodily fluids of an infected person or virus-contaminated objects such as clothing, bedding, and fabrics, as well as through mother-to-child transmission and sexual transmission. However, monkeypox is far less contagious than smallpox, so human-to-human transmission is uncommon.